EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling

EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling

Abstract Osteosarcoma (OS) is a rare tumor of the bone occurring mainly in young adults accounting for 5% of all childhood cancers. Because of the limited therapeutic options, there has been no survival improvement for OS patients in the past 40 years. The epidermal growth factor receptor (EGFR) is...

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Bibliographic Details
Main Authors: Markus Linder, Elisabeth Glitzner, Sriram Srivatsa, Latifa Bakiri, Kazuhiko Matsuoka, Parastoo Shahrouzi, Monika Dumanic, Philipp Novoszel, Thomas Mohr, Oliver Langer, Thomas Wanek, Markus Mitterhauser, Erwin F Wagner, Maria Sibilia
Format: Article
Language:English
Published: Wiley 2018-11-01
Series:EMBO Molecular Medicine
Subjects:
c‐Fos
CREB
epidermal growth factor receptor
osteosarcoma
RSK2
Online Access:https://doi.org/10.15252/emmm.201809408

Internet

https://doi.org/10.15252/emmm.201809408

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