Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

<p>Abstract</p> <p>Background</p> <p>The Hedgehog (Hh) signaling pathway is vital to animal development as it mediates the differentiation of multiple cell types during embryogenesis. In adults, Hh signaling can be activated to facilitate tissue maintenance and repair....

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Main Authors: Shulok Janine, Jones Simon, Wang Frank Y, Bumcrot David, Dudek Henryk, Wichterle Hynek, Guicherit Oivin, Bottega Steve, Zhang Xiaoyan M, Frank-Kamenetsky Maria, Rubin Lee L, Porter Jeffery A
Format: Article
Language:English
Published: BMC 2002-11-01
Series:Journal of Biology
Online Access:http://jbiol.com/content/1/2/10

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http://jbiol.com/content/1/2/10

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