Downregulation of MiR-31 stimulates expression of LATS2 via the hippo pathway and promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma

Downregulation of MiR-31 stimulates expression of LATS2 via the hippo pathway and promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma

Abstract Background Dysregulation of miRNAs is associated with cancer development by coordinately suppressing abundant target genes. Emerging evidence indicates that miR-31 plays a dual role in tumorigenicity. However, whether miR-31 plays as an oncogene in esophageal squamous cell carcinoma (ESCC)...

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Bibliographic Details
Main Authors: Yanping Gao, Jun Yi, Kai Zhang, Fan Bai, Bing Feng, Rui Wang, Xiaoyuan Chu, Longbang Chen, Haizhu Song
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
miR-31
LATS2
Hippo pathway
TAZ
EMT
Esophageal squamous cell carcinoma
Online Access:http://link.springer.com/article/10.1186/s13046-017-0622-1

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http://link.springer.com/article/10.1186/s13046-017-0622-1

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