Pan‐tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation

Pan‐tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation

Abstract Alternative polyadenylation (APA) is a major layer of gene regulation. However, it has recently been argued that most APA represents molecular noise. To clarify their functional relevance and evolution, we quantified allele‐specific APA patterns in multiple tissues from an F1 hybrid mouse....

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Bibliographic Details
Main Authors: Yisheng Li, Bernhard Schaefke, Xudong Zou, Min Zhang, Florian Heyd, Wei Sun, Bin Zhang, Guipeng Li, Weizheng Liang, Yuhao He, Juexiao Zhou, Yunfei Li, Liang Fang, Yuhui Hu, Wei Chen
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Molecular Systems Biology
Subjects:
alternative polyadenylation
error hypothesis
gene regulation
neutral theory of molecular evolution
regulatory evolution
Online Access:https://doi.org/10.15252/msb.20199367

Internet

https://doi.org/10.15252/msb.20199367

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