Therapeutic Effects in a Transient Middle Cerebral Artery Occlusion Rat Model by Nose-To-Brain Delivery of Anti-TNF-Alpha siRNA with Cell-Penetrating Peptide-Modified Polymer Micelles

Therapeutic Effects in a Transient Middle Cerebral Artery Occlusion Rat Model by Nose-To-Brain Delivery of Anti-TNF-Alpha siRNA with Cell-Penetrating Peptide-Modified Polymer Micelles

We previously reported that siRNA delivery to the brain is improved by the nose-to-brain delivery route and by conjugation with polyethylene glycol-polycaprolactone (PEG-PCL) polymer micelles and the cell-penetrating peptide, Tat (PEG-PCL-Tat). In this study, we evaluated the nose-to-brain delivery...

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Bibliographic Details
Main Authors: Takanori Kanazawa, Takumi Kurano, Hisako Ibaraki, Yuuki Takashima, Toyofumi Suzuki, Yasuo Seta
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Pharmaceutics
Subjects:
nose-to-brain delivery
siRNA
cell-penetrating peptide
polymer micelle
transient middle cerebral artery occlusion
cerebral ischemia-reperfusion injury
Online Access:https://www.mdpi.com/1999-4923/11/9/478

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https://www.mdpi.com/1999-4923/11/9/478

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