Breast Tumor Cell Invasion and Pro-Invasive Activity of Cancer-Associated Fibroblasts Co-Targeted by Novel Urokinase-Derived Decapeptides

Breast Tumor Cell Invasion and Pro-Invasive Activity of Cancer-Associated Fibroblasts Co-Targeted by Novel Urokinase-Derived Decapeptides

Among peritumoral cells, cancer-associated fibroblasts (CAFs) are major facilitators of tumor progression. This study describes the effects of two urokinase-derived, novel decapeptides, denoted as Pep 1 and its cyclic derivative Pep 2. In a mouse model of tumor dissemination, using HT1080 fibrosarco...

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Bibliographic Details
Main Authors: Stefania Belli, Paola Franco, Francesca Iommelli, Anna De Vincenzo, Diego Brancaccio, Marialucia Telesca, Francesco Merlino, Ettore Novellino, Marie Ranson, Silvana Del Vecchio, Paolo Grieco, Alfonso Carotenuto, Maria Patrizia Stoppelli
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
tumor microenvironment
metastatic dissemination
breast cancer cell invasion
v integrin
cancer-associated fibroblasts
Online Access:https://www.mdpi.com/2072-6694/12/9/2404

Internet

https://www.mdpi.com/2072-6694/12/9/2404

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