Novel phenyl-urea derivatives as dual-target ligands that can activate both GK and PPARγ

Novel phenyl-urea derivatives as dual-target ligands that can activate both GK and PPARγ

A series of novel phenyl-urea derivatives which can simultaneously activate glucokinase (GK) and peroxisome proliferator-activated receptor γ (PPARγ) was designed and prepared, and their activation of GK and PPARγ was evaluated. The structure–activity relationships of these compounds are also descri...

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Bibliographic Details
Main Authors: Lijian Zhang, Kang Tian, Yongqiang Li, Lei Lei, Aifang Qin, Lijuan Zhang, Hongrui Song, Lianchao Huo, Lijing Zhang, Xiaofeng Jin, Zhufang Shen, Zhiqiang Feng
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Type 2 diabetes
GK activators
PPARγ agonists
Dual action
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383512001414

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http://www.sciencedirect.com/science/article/pii/S2211383512001414

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