Mechanisms of FH Protection Against Neovascular AMD

Mechanisms of FH Protection Against Neovascular AMD

A common allele (402H) of the complement factor H (FH) gene is the major risk factor for age-related macular degeneration (AMD), the leading cause of blindness in the elderly population. Development and progression of AMD involves vascular and inflammatory components partly by deregulation of the al...

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Main Authors: Céline Borras, Kimberley Delaunay, Yousri Slaoui, Toufik Abache, Sylvie Jorieux, Marie-Christine Naud, Mohamed El Sanharawi, Emmanuelle Gelize, Patricia Lassiaz, Na An, Laura Kowalczuk, Cédric Ayassami, Alexandre Moulin, Francine Behar-Cohen, Frédéric Mascarelli, Virginie Dinet
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
AMD
complement factor H
FH Y402H polymorphism
TSP-1
therapeutic target
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00443/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00443/full

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