Quantitative Evaluation of the Compatibility Effects of Huangqin Decoction on the Treatment of Irinotecan-Induced Gastrointestinal Toxicity Using Untargeted Metabolomics

Quantitative Evaluation of the Compatibility Effects of Huangqin Decoction on the Treatment of Irinotecan-Induced Gastrointestinal Toxicity Using Untargeted Metabolomics

Huangqin decoction (HQD), a traditional Chinese medicine (TCM), has been widely used to treat gastrointestinal syndrome in China for thousands of years. Chemotherapy drug irinotecan (CPT-11) is used clinically to treat various kinds of cancers but limited by its side effects, especially delayed diar...

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Bibliographic Details
Main Authors: Zun-Jian Zhang, Feng-Guo Xu, Dong-Ni Cui, Xu Wang, Jia-Qing Chen, Bo Lv, Pei Zhang, Wei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Pharmacology
Subjects:
Huangqin decoction
delayed diarrhea
metabolomics
metabolites deregulation score
relative area under the curve
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00211/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00211/full

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