Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore

Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore

First-generation nonsteroidal androgen receptor (AR) antagonists, such as flutamide (<b>2a</b>) and bicalutamide (<b>3</b>), are effective for most prostate cancer patients, but resistance often appears after several years due to the mutation of AR. Second-generation AR antag...

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Bibliographic Details
Main Authors: Hitomi Koga, Mai Negishi, Marie Kinoshita, Shinya Fujii, Shuichi Mori, Mari Ishigami-Yuasa, Emiko Kawachi, Hiroyuki Kagechika, Aya Tanatani
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer
cell proliferation
coumarin
cis-amide
Online Access:https://www.mdpi.com/1422-0067/21/15/5584

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https://www.mdpi.com/1422-0067/21/15/5584

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