Inhibition of dipeptidyl peptidase IV (DPP-IV) by proline containing casein-derived peptides

Dipeptides with a C terminal Pro inhibit dipeptidyl peptidase IV (DPP-IV), a key enzyme in incretin hormone processing. It was hypothesised that tri- and tetrapeptides with a proline at the C-terminus may also be DPP-IV inhibitors. Therefore, an in silico hydrolysis approach was used to release shor...

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Bibliographic Details
Main Authors: Alice B. Nongonierma, Richard J. FitzGerald
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Journal of Functional Foods
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464613002119