Celastrol, an NF-κB inhibitor, ameliorates hypercalciuria and articular cartilage lesions in a mouse model of secondary osteoporosis

Celastrol, an NF-κB inhibitor, ameliorates hypercalciuria and articular cartilage lesions in a mouse model of secondary osteoporosis

Notwithstanding compelling contribution of NF-κB to the progression of osteoporosis has been reported, little is known regarding direct inhibition of NF-κB benefiting osteoporosis. In this study, therefore, we evaluated the role of celastrol, an NF-κB inhibitor, in a mouse model of secondary osteopo...

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Bibliographic Details
Main Authors: Xiaodong Liu, Feng Cai, Yan Zhang, Anli Yang, Liang Liu
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Journal of Pharmacological Sciences
Subjects:
Celastrol
NF-κB inhibitor
Secondary osteoporosis
Cartilage lesions
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316000220

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http://www.sciencedirect.com/science/article/pii/S1347861316000220

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