Pro-inflammatory conditions promote neuronal damage mediated by Amyloid Precursor Protein and decrease its phagocytosis and degradation by microglial cells in culture

Pro-inflammatory conditions promote neuronal damage mediated by Amyloid Precursor Protein and decrease its phagocytosis and degradation by microglial cells in culture

Aberrant handling of Amyloid Precursor Protein (APP) and β-amyloid (Aβ), glial activation and inflammation are key events in Alzheimer’s disease. We set out to determine the role of inflammation on microglial reactivity against APP. We studied microglia-mediated neurotoxicity, uptake and degradation...

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Bibliographic Details
Main Authors: Rommy von Bernhardi, Gigliola Ramírez, Rodrigo Toro, Jaime Eugenín
Format: Article
Language:English
Published: Elsevier 2007-04-01
Series:Neurobiology of Disease
Subjects:
Alzheimer’s disease
APP processing
Astrocytes
β-amyloid
Glia
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106003196

Internet

http://www.sciencedirect.com/science/article/pii/S0969996106003196

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