Synchronous recruitment of epigenetic modifiers to endotoxin synergistically activated Tnf-α gene in acute kidney injury.

Synchronous recruitment of epigenetic modifiers to endotoxin synergistically activated Tnf-α gene in acute kidney injury.

As a consequence of acute kidney injury (AKI), proximal tubular cells hyperrespond to endotoxin (lipopolysaccharide, LPS) by exaggerated renal Tnf-α Production. This LPS hyperresponsiveness is transcriptionally mediated. The epigenetic pathways that control these responses are unknown.We applied mul...

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Bibliographic Details
Main Authors: Karol Bomsztyk, Steve Flanagin, Daniel Mar, Michal Mikula, Ali Johnson, Richard Zager, Oleg Denisenko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3728219?pdf=render

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http://europepmc.org/articles/PMC3728219?pdf=render

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