Network evolution: rewiring and signatures of conservation in signaling.

The analysis of network evolution has been hampered by limited availability of protein interaction data for different organisms. In this study, we investigate evolutionary mechanisms in Src Homology 3 (SH3) domain and kinase interaction networks using high-resolution specificity profiles. We constru...

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Bibliographic Details
Main Authors: Mark G F Sun, Martin Sikora, Michael Costanzo, Charles Boone, Philip M Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3305342?pdf=render