Human Intestinal Enteroids Model MHC-II in the Gut Epithelium

Human Intestinal Enteroids Model MHC-II in the Gut Epithelium

The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, “mini-guts” derived from small intestinal crypt stem cells, and show that the intracellular MHC-II peptide-pathway is...

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Bibliographic Details
Main Authors: Jonathan E. Wosen, Alexandra Ilstad-Minnihan, Julia Y. Co, Wei Jiang, Dhriti Mukhopadhyay, Nielsen Q. Fernandez-Becker, Calvin J. Kuo, Manuel R. Amieva, Elizabeth D. Mellins
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
MHC-II
epithelial cells
enteroid culture
antigen presentation
mucosal immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01970/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01970/full

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