Artificial T Cell Adaptor Molecule-Transduced TCR-T Cells Demonstrated Improved Proliferation Only When Transduced in a Higher Intensity

Artificial T Cell Adaptor Molecule-Transduced TCR-T Cells Demonstrated Improved Proliferation Only When Transduced in a Higher Intensity

An artificial T cell adaptor molecule (ATAM) was generated to improve persistence of T cell receptor (TCR) gene-transduced T (TCR-T) cells compared to such persistence in a preceding study. ATAMs are gene-modified CD3ζ with the intracellular domain of 4-1BB inserted in the middle of CD3ζ. NY-ESO-1 T...

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Bibliographic Details
Main Authors: Toshiyasu Sakai, Seitaro Terakura, Kotaro Miyao, Shingo Okuno, Yoshitaka Adachi, Koji Umemura, Jakrawadee Julamanee, Keisuke Watanabe, Hiroshi Hamana, Hiroyuki Kishi, Judith Leitner, Peter Steinberger, Tetsuya Nishida, Makoto Murata, Hitoshi Kiyoi
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
T cell receptor gene insertion
artificial adaptor molecule
gene-modified T cell therapy
CD3ζ gene modification
adaptor molecule gene-insertion intensity
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520301315

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http://www.sciencedirect.com/science/article/pii/S2372770520301315

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