L-Arginine/Nitric Oxide Pathway Is Altered in Colorectal Cancer and Can Be Modulated by Novel Derivatives from Oxicam Class of Non-Steroidal Anti-Inflammatory Drugs

L-Arginine/Nitric Oxide Pathway Is Altered in Colorectal Cancer and Can Be Modulated by Novel Derivatives from Oxicam Class of Non-Steroidal Anti-Inflammatory Drugs

L-arginine/nitric oxide pathway metabolites are altered in colorectal cancer (CRC). We evaluated underlying changes in pathway enzymes in 55 paired tumor/tumor-adjacent samples and 20 normal mucosa using quantitative-PCR and assessed the impact of classic and novel oxicam analogues on enzyme express...

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Bibliographic Details
Main Authors: Małgorzata Krzystek-Korpacka, Berenika Szczęśniak-Sięga, Izabela Szczuka, Paulina Fortuna, Marek Zawadzki, Agnieszka Kubiak, Magdalena Mierzchała-Pasierb, Mariusz G. Fleszar, Łukasz Lewandowski, Paweł Serek, Natalia Jamrozik, Katarzyna Neubauer, Jerzy Wiśniewski, Radosław Kempiński, Wojciech Witkiewicz, Iwona Bednarz-Misa
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
arginase (ARG)
nitric oxide synthase (NOS)
dimethylarginine dimethylaminohydrolase (DDAH)
protein methyltransferases (PRMT)
asymmetric dimethylarginine (ADMA)
symmetric dimethylarginine (SDMA)
Online Access:https://www.mdpi.com/2072-6694/12/9/2594

Internet

https://www.mdpi.com/2072-6694/12/9/2594

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