Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1G93A female mice

Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1G93A female mice

Neuroinflammation is one of the main physiopathological mechanisms of amyotrophic lateral sclerosis (ALS), produced by the chronic activation of microglia in the CNS. This process is triggered by the persistent activation of the ATP-gated P2X7 receptor (P2RX7, hereafter referred to as P2X7R). The pr...

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Bibliographic Details
Main Authors: Cristina Ruiz-Ruiz, Nuria García-Magro, Pilar Negredo, Carlos Avendaño, Anindya Bhattacharya, Marc Ceusters, Antonio G. García
Format: Article
Language:English
Published: The Company of Biologists 2020-10-01
Series:Disease Models & Mechanisms
Subjects:
amyotrophic lateral sclerosis
sod1g93a mice
neuroinflammation
p2x7 receptor
purinergic signaling
Online Access:http://dmm.biologists.org/content/13/10/dmm045732

Internet

http://dmm.biologists.org/content/13/10/dmm045732

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