Evaluation of Intra-Articular Amikacin Administration in an Equine Non-inflammatory Joint Model to Identify Effective Bactericidal Concentrations While Minimizing Cytotoxicity

Evaluation of Intra-Articular Amikacin Administration in an Equine Non-inflammatory Joint Model to Identify Effective Bactericidal Concentrations While Minimizing Cytotoxicity

Septic arthritis causes significant morbidity and mortality in veterinary and human clinical practice and is increasingly complicated by multidrug-resistant infections. Intra-articular (IA) antibiotic administration achieves high local drug concentrations but is considered off-label usage, and appro...

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Bibliographic Details
Main Authors: Lynn Pezzanite, Lyndah Chow, Dean Hendrickson, Daniel L. Gustafson, A Russell Moore, Jason Stoneback, Gregg M. Griffenhagen, Gabriella Piquini, Jennifer Phillips, Paul Lunghofer, Steven Dow, Laurie R. Goodrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Veterinary Science
Subjects:
intra-articular
antibiotic
aminoglycoside
amikacin
cartilage
horse
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2021.676774/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2021.676774/full

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