Structure-Based Virtual Screening to Identify Novel Potential Compound as an Alternative to Remdesivir to Overcome the RdRp Protein Mutations in SARS-CoV-2

Structure-Based Virtual Screening to Identify Novel Potential Compound as an Alternative to Remdesivir to Overcome the RdRp Protein Mutations in SARS-CoV-2

The number of confirmed COVID-19 cases is rapidly increasing with no direct treatment for the disease. Few repurposed drugs, such as Remdesivir, Chloroquine, Hydroxychloroquine, Lopinavir, and Ritonavir, are being tested against SARS-CoV-2. Remdesivir is the drug of choice for Ebola virus disease an...

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Bibliographic Details
Main Authors: Thirumal Kumar D, Nishaat Shaikh, Udhaya Kumar S, George Priya Doss C, Hatem Zayed
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
SARS-CoV-2
COVID-19
remdesivir
virtual screening
RdRp
mutations
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.645216/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.645216/full

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