Deficiency in Tissue Non-Specific Alkaline Phosphatase Leads to Steatohepatitis in Mice Fed a High Fat Diet Similar to That Produced by a Methionine and Choline Deficient Diet

Deficiency in Tissue Non-Specific Alkaline Phosphatase Leads to Steatohepatitis in Mice Fed a High Fat Diet Similar to That Produced by a Methionine and Choline Deficient Diet

The liver expresses tissue-nonspecific alkaline phosphatase (TNAP), which may participate in the defense against bacterial components, in cell regulation as part of the purinome or in bile secretion, among other roles. We aimed to study the role of TNAP in the development of hepatosteatosis. TNAP<...

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Bibliographic Details
Main Authors: Reyes Gámez-Belmonte, Mireia Tena-Garitaonaindia, Cristina Hernández-Chirlaque, Samir Córdova, Diego Ceacero-Heras, Fermín Sánchez de Medina, Olga Martínez-Augustin
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
methionine and choline diet
metabolic syndrome
biliary acids
tissue non-specific alkaline phosphatase
steatohepatitis
Online Access:https://www.mdpi.com/1422-0067/22/1/51

Internet

https://www.mdpi.com/1422-0067/22/1/51

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