Impact of charged particle exposure on homologous DNA double-strand break repair in human blood-derived cells

Impact of charged particle exposure on homologous DNA double-strand break repair in human blood-derived cells

Ionizing radiation generates DNA double-strand breaks (DSB) which, unless faithfully repaired, can generate chromosomal rearrangements in hematopoietic stem and/or progenitor cells (HSPC), potentially priming the cells towards a leukemic phenotype. Using an enhanced green fluorescent protein (EGFP)-...

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Bibliographic Details
Main Authors: Melanie eRall, Daniela eKraft, Meta eVolcic, Aljona eCucu, Elena eNasonova, Gisela eTaucher-Scholz, Halvard eBönig, Lisa eWiesmüller, Claudia eFournier
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Oncology
Subjects:
DNA double-strand break repair
charged particles
Hematopoietic stem and progenitor cells
Radiation-induced leukemia
breakpoint cluster region
chromosomal breaks
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00250/full

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http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00250/full

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