5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

5-Fluorouracil (5-FU) is a commonly used chemo drug to treat cancer patients. Using in vitro 5-FU treated organoids and in vivo 5-FU treated human cancer data, the authors describe a 5-FU mutational signature that is similar to COSMIC signature 17 frequently observed in untreated cancers

Bibliographic Details
Main Authors: Sharon Christensen, Bastiaan Van der Roest, Nicolle Besselink, Roel Janssen, Sander Boymans, John W. M. Martens, Marie-Laure Yaspo, Peter Priestley, Ewart Kuijk, Edwin Cuppen, Arne Van Hoeck
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12594-8

Internet

https://doi.org/10.1038/s41467-019-12594-8

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