Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity.

Use of some HIV-1 nucleoside reverse transcriptase inhibitors (NRTI) is associated with severe adverse events. However, the exact mechanisms behind their toxicity has not been fully understood. Mitochondrial dysfunction after chronic exposure to specific NRTIs has predominantly been assigned to mito...

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Bibliographic Details
Main Authors: Reuben L Smith, Josephine M E Tan, Martijs J Jonker, Aldo Jongejan, Thomas Buissink, Steve Veldhuijzen, Antoine H C van Kampen, Stanley Brul, Hans van der Spek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5667870?pdf=render