The combined effect of dichloroacetate and 3-bromopyruvate on glucose metabolism in colorectal cancer cell line, HT-29; the mitochondrial pathway apoptosis

The combined effect of dichloroacetate and 3-bromopyruvate on glucose metabolism in colorectal cancer cell line, HT-29; the mitochondrial pathway apoptosis

Abstract Background 5-Fluorouracil (5-FU) is regarded as the first line treatment for colorectal cancer; however, its effectiveness is limited by drug resistance. The ultimate goal of cancer therapy is induction of cancer cell death to achieve an effective outcome with minimal side effects. The pres...

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Bibliographic Details
Main Authors: Hojatolla Nikravesh, Mohammad Javad Khodayar, Babak Behmanesh, Masoud Mahdavinia, Ali Teimoori, Soheila Alboghobeish, Leila Zeidooni
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Cancer
Subjects:
Apoptosis
3-Bromopyruvate
Dichloroacetate
Colorectal cancer cells
5-fluorouracil
Online Access:https://doi.org/10.1186/s12885-021-08564-3

Internet

https://doi.org/10.1186/s12885-021-08564-3

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