Is Cell Death Primary or Secondary in the Pathophysiology of Idiopathic Parkinson’s Disease?

Is Cell Death Primary or Secondary in the Pathophysiology of Idiopathic Parkinson’s Disease?

Currently, the pathophysiology of idiopathic Parkinson’s disease is explained by a loss of mainly dopaminergic nerve cells that causes a neurotransmitter deficiency. In the final stage of the disease, there is a marked loss of neurons in the substantia nigra. In addition, Lewy bodies can be found in...

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Bibliographic Details
Main Author: Walter J. Schulz-Schaeffer
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Biomolecules
Subjects:
neurodegenerative disease
α-synuclein
protein aggregate
synaptic dysfunction
Lewy bodies
cell death
Online Access:http://www.mdpi.com/2218-273X/5/3/1467

Internet

http://www.mdpi.com/2218-273X/5/3/1467

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