Ceftriaxone Relieves Trigeminal Neuropathic Pain Through Suppression of Spatiotemporal Synaptic Plasticity via Restoration of Glutamate Transporter 1 in the Medullary Dorsal Horn

Ceftriaxone Relieves Trigeminal Neuropathic Pain Through Suppression of Spatiotemporal Synaptic Plasticity via Restoration of Glutamate Transporter 1 in the Medullary Dorsal Horn

Using a rat model of trigeminal neuropathic pain (TNP) produced by chronic compression of the infraorbital nerve (CCI-ION), we investigated the analgesic effect and the underlying mechanisms of ceftriaxone (Cef), a β-lactam antibiotic, that is thought to be a potent stimulator of glutamate transport...

Full description

Bibliographic Details
Main Authors: Xiao Luo, Ting He, Yan Wang, Jiang-Lin Wang, Xue-Bin Yan, Hao-Cheng Zhou, Rui-Rui Wang, Rui Du, Xiao-Liang Wang, Jun Chen, Dong Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
trigeminal neuropathic pain
glutamate transporter 1
ceftriaxone
synaptic plasticity
long-term potentiation
medullary dorsal horn
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00199/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00199/full

Similar Items