Data-Driven Modeling Identifies TIRAP-Independent MyD88 Activation Complex and Myddosome Assembly Strategy in LPS/TLR4 Signaling

Data-Driven Modeling Identifies TIRAP-Independent MyD88 Activation Complex and Myddosome Assembly Strategy in LPS/TLR4 Signaling

TLR4 complexes are essential for the initiation of the LPS-induced innate immune response. The Myddosome, which mainly contains TLR4, TIRAP, MyD88, IRAK1/4 and TRAF6 proteins, is regarded as a major complex of TLR4. Although the Myddosome has been well studied, a quantitative description of the Mydd...

Full description

Bibliographic Details
Main Authors: Xiang Li, Chuan-Qi Zhong, Zhiyong Yin, Hong Qi, Fei Xu, Qingzu He, Jianwei Shuai
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
higher-order assembly strategy
LPS signaling
mathematical modeling
SWATH-MS
systems biology
TLR4 complexes
Online Access:https://www.mdpi.com/1422-0067/21/9/3061

Internet

https://www.mdpi.com/1422-0067/21/9/3061

Similar Items