Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease

Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease

Background: Bicuspid aortic valve (BAV) is the most common congenital cardiovascular disease in general population and is frequently associated with the development of thoracic aortic aneurysm (TAA). There is no effective strategy to intervene with TAA progression due to an incomplete understanding...

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Bibliographic Details
Main Authors: Mieradilijiang Abudupataer, Shichao Zhu, Shiqiang Yan, Kehua Xu, Jingjing Zhang, Shaman Luo, Wenrui Ma, Md Fazle Alam, Yuyi Tang, Hui Huang, Nan Chen, Li Wang, Guoquan Yan, Jun Li, Hao Lai, Chunsheng Wang, Kai Zhu, Weijia Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
organ-on-a-chip
thoracic aortic aneurysm
bicuspid aortic valve
mitochondrial dynamics
human aortic
smooth muscle cells
Online Access:https://elifesciences.org/articles/69310

Internet

https://elifesciences.org/articles/69310

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