Lipoxin A4 protects primary spinal cord neurons from Erastin‐induced ferroptosis by activating the Akt/Nrf2/HO‐1 signaling pathway

Lipoxin A4 protects primary spinal cord neurons from Erastin‐induced ferroptosis by activating the Akt/Nrf2/HO‐1 signaling pathway

Ferroptosis is an iron‐dependent programmed cell death, which participates in the pathogenesis of spinal cord injury (SCI). Our previous study has revealed that Lipoxin A4 (LXA4) exerts a protective role in SCI. Here, we investigated whether LXA4 can protect SCI through inhibiting neuronal ferroptos...

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Bibliographic Details
Main Authors: Na Wei, Tan Lu, Libin Yang, Yonghan Dong, Xiaotan Liu
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:FEBS Open Bio
Subjects:
Akt/Nrf2/HO‐1
Erastin
ferroptosis
lipoxin A4
primary spinal cord neurons
spinal cord injury
Online Access:https://doi.org/10.1002/2211-5463.13203

Internet

https://doi.org/10.1002/2211-5463.13203

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