Metformin regulates the Th17/Treg balance by glycolysis with TIGAR in hepatic ischemia-reperfusion injury

Metformin regulates the Th17/Treg balance by glycolysis with TIGAR in hepatic ischemia-reperfusion injury

The balance of Th17/Treg plays an important role in hepatic ischemia–reperfusion (I/R) injury. Glycolysis and glutaminolysis for energy metabolism governs the differentiate of CD 4+ T-cells to Th17/Treg. Metformin can regulate glucose metabolism in the liver, but its protective effect on I/R liver i...

Full description

Bibliographic Details
Main Authors: Aiwen Jiang, Peishan Du, Yunning Liu, Jiekun Pu, Jinzheng Shi, Heming Zhang
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Journal of Pharmacological Sciences
Subjects:
Th17/Treg balance
Hepatic ischemia–reperfusion (I/R) injury
Metformin
Glycolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861321000074

Internet

http://www.sciencedirect.com/science/article/pii/S1347861321000074

Similar Items