Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation.

Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation.

A large pool of preexisting alloreactive effector T cells can cause allogeneic graft rejection following transplantation. However, it is possible to induce transplant tolerance by altering the balance between effector and regulatory T (Treg) cells. Among the various Treg-cell types, Foxp3(+)Treg and...

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Bibliographic Details
Main Authors: Nicola Gagliani, Silvia Gregori, Tatiana Jofra, Andrea Valle, Angela Stabilini, David M Rothstein, Mark Atkinson, Maria Grazia Roncarolo, Manuela Battaglia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3235119?pdf=render

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http://europepmc.org/articles/PMC3235119?pdf=render

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