Expression of MATE1, P-gp, OCTN1 and OCTN2, in epithelial and immune cells in the lung of COPD and healthy individuals

Expression of MATE1, P-gp, OCTN1 and OCTN2, in epithelial and immune cells in the lung of COPD and healthy individuals

Abstract Background Several inhaled drugs are dependent on organic cation transporters to cross cell membranes. To further evaluate their potential to impact on inhaled drug disposition, the localization of MATE1, P-gp, OCTN1 and OCTN2 were investigated in human lung. Methods Transporter proteins we...

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Bibliographic Details
Main Authors: Tove Berg, Tove Hegelund-Myrbäck, Johan Öckinger, Xiao-Hong Zhou, Marie Brännström, Michael Hagemann-Jensen, Viktoria Werkström, Janeric Seidegård, Johan Grunewald, Magnus Nord, Lena Gustavsson
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Respiratory Research
Subjects:
MATE1
P-gp
OCTN1
OCTN2
Immunohistochemistry
COPD
Online Access:http://link.springer.com/article/10.1186/s12931-018-0760-9

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http://link.springer.com/article/10.1186/s12931-018-0760-9

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