Hyperhomocysteinemia leads to exacerbation of ischemic brain damage: Role of GluN2A NMDA receptors

Hyperhomocysteinemia leads to exacerbation of ischemic brain damage: Role of GluN2A NMDA receptors

Hyperhomocysteinemia has been implicated in several neurodegenerative disorders including ischemic stroke. However, the pathological consequences of ischemic insult in individuals predisposed to hyperhomocysteinemia and the associated etiology are unknown. In this study, we evaluated the outcome of...

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Bibliographic Details
Main Authors: Ankur Jindal, Sathyanarayanan Rajagopal, Lucas Winter, Joshua W. Miller, Donald W. Jacobsen, Jonathan Brigman, Andrea M. Allan, Surojit Paul, Ranjana Poddar
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neurobiology of Disease
Subjects:
Hyperhomocysteinemia
GluN2A-NMDA receptors (also known as NR2A-NMDA receptors)
GluN2B-NMDA receptors (also known as NR2B-NMDA receptors)
ERK MAPK
GluN2A-NMDA receptor knockout mice
Middle cerebral artery occlusion
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118303255

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http://www.sciencedirect.com/science/article/pii/S0969996118303255

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