The Updating of Biological Functions of Methyltransferase SETDB1 and Its Relevance in Lung Cancer and Mesothelioma

The Updating of Biological Functions of Methyltransferase SETDB1 and Its Relevance in Lung Cancer and Mesothelioma

SET domain bifurcated 1 (SETDB1) is a histone H3 lysine 9 (H3K9) methyltransferase that exerts important effects on epigenetic gene regulation. SETDB1 complexes (SETDB1-KRAB-KAP1, SETDB1-DNMT3A, SETDB1-PML, SETDB1-ATF7IP-MBD1) play crucial roles in the processes of histone methylation, transcription...

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Bibliographic Details
Main Authors: Li Yuan, Boshu Sun, Liangliang Xu, Limin Chen, Wenbin Ou
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
methyltransferase
SETDB1
function
lung cancer
mesothelioma
Online Access:https://www.mdpi.com/1422-0067/22/14/7416

Internet

https://www.mdpi.com/1422-0067/22/14/7416

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