Entresto protected the cardiomyocytes and preserved heart function in cardiorenal syndrome rat fed with high-protein diet through regulating the oxidative stress and Mfn2-mediated mitochondrial functional integrity

Entresto protected the cardiomyocytes and preserved heart function in cardiorenal syndrome rat fed with high-protein diet through regulating the oxidative stress and Mfn2-mediated mitochondrial functional integrity

This study tested the hypothesis that Entresto (En) therapy protected the cardiomyocytes and heart function in cardiorenal syndrome (CRS) rats fed with high-protein diet (HPD) through regulating the oxidative-stress and Mfn2-mediated mitochondrial functional integrity. En (12.5 μM for the in-vitro s...

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Bibliographic Details
Main Authors: Jui-Ning Yeh, Ya Yue, Yi-Ching Chu, Chi-Ruei Huang, Chih-Chao Yang, John Y. Chiang, Hon-Kan Yip, Jun Guo
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Entresto
Mitofusin 2
Oxidative stress
Mitochondrial damage
Left ventricular ejection fraction (LVEF)
Cardiorenal syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221010283

Internet

http://www.sciencedirect.com/science/article/pii/S0753332221010283

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