Trace Elements Status and Metallothioneins DNA Methylation Influence Human Hepatocellular Carcinoma Survival Rate

Trace Elements Status and Metallothioneins DNA Methylation Influence Human Hepatocellular Carcinoma Survival Rate

BackgroundMechanisms underlying hepatocellular carcinoma (HCC) development are largely unknown. The role of trace elements and proteins regulating metal ions homeostasis, i.e. metallothioneins (MTs), recently gained an increased interest. Object of the study was to investigate the role of promoter D...

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Bibliographic Details
Main Authors: Silvia Udali, Domenica De Santis, Filippo Mazzi, Sara Moruzzi, Andrea Ruzzenente, Annalisa Castagna, Patrizia Pattini, Greta Beschin, Antonia Franceschi, Alfredo Guglielmi, Nicola Martinelli, Francesca Pizzolo, Francesca Ambrosani, Oliviero Olivieri, Sang-Woon Choi, Simonetta Friso
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
copper
DNA methylation
epigenetics
hepatocellular carcinoma
MT1G
MT1H
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.596040/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.596040/full

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