A novel approach to determine two optimal cut-points of a continuous predictor with a U-shaped relationship to hazard ratio in survival data: simulation and application

A novel approach to determine two optimal cut-points of a continuous predictor with a U-shaped relationship to hazard ratio in survival data: simulation and application

Abstract Background In clinical and epidemiological researches, continuous predictors are often discretized into categorical variables for classification of patients. When the relationship between a continuous predictor and log relative hazards is U-shaped in survival data, there is a lack of a sati...

Full description

Bibliographic Details
Main Authors: Yimin Chen, Jialing Huang, Xianying He, Yongxiang Gao, Gehendra Mahara, Zhuochen Lin, Jinxin Zhang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Medical Research Methodology
Subjects:
Optimal cut-points
Discretization
Categorize
U shape
Cox regression model
Survival analysis
Online Access:http://link.springer.com/article/10.1186/s12874-019-0738-4

Internet

http://link.springer.com/article/10.1186/s12874-019-0738-4

Similar Items