Metabolic Activation and Covalent Protein Binding of Berberrubine: Insight into the Underlying Mechanism Related to Its Hepatotoxicity

Metabolic Activation and Covalent Protein Binding of Berberrubine: Insight into the Underlying Mechanism Related to Its Hepatotoxicity

Kai Wang,1,* Jinqiu Rao,1,* Tingting Zhang,1 Qing Gao,2 Jichao Zhang,3 Chenxi Guang,3 Liqin Ding,3 Feng Qiu1,3 1School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, People’s Republic of China; 2School of Integrative Medicine, Tianjin Univers...

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Bibliographic Details
Main Authors: Wang K, Rao J, Zhang T, Gao Q, Zhang J, Guang C, Ding L, Qiu F
Format: Article
Language:English
Published: Dove Medical Press 2020-10-01
Series:Drug Design, Development and Therapy
Subjects:
berberrubine
hepatotoxicity
metabolic activation
protein modification
Online Access:https://www.dovepress.com/metabolic-activation-and-covalent-protein-binding-of-berberrubine-insi-peer-reviewed-article-DDDT

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https://www.dovepress.com/metabolic-activation-and-covalent-protein-binding-of-berberrubine-insi-peer-reviewed-article-DDDT

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