FGFR1 amplification or overexpression and hormonal resistance in luminal breast cancer: rationale for a triple blockade of ER, CDK4/6, and FGFR1

FGFR1 amplification or overexpression and hormonal resistance in luminal breast cancer: rationale for a triple blockade of ER, CDK4/6, and FGFR1

Abstract Background FGFR1 amplification, but not overexpression, has been related to adverse prognosis in hormone-positive breast cancer (HRPBC). Whether FGFR1 overexpression and amplification are correlated, what is their distribution among luminal A or B HRPBC, and if there is a potential differen...

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Bibliographic Details
Main Authors: Silvana Mouron, Luis Manso, Eduardo Caleiras, Jose L. Rodriguez-Peralto, Oscar M. Rueda, Carlos Caldas, Ramon Colomer, Miguel Quintela-Fandino, Maria J. Bueno
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Breast Cancer Research
Subjects:
FGFR1 overexpression
FGFR1 amplification
Luminal breast cancer
Rogaratinib
Palbociclib
Online Access:https://doi.org/10.1186/s13058-021-01398-8

Internet

https://doi.org/10.1186/s13058-021-01398-8

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