A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes

Convenient and fast methods to introduce 11C into organic molecules are of great help for molecular imaging studies. Here, the authors developed an efficient incorporation of [11C]CO2 and [11C]CH3I into molecules via a fluoride-mediated desilylation process.

Bibliographic Details
Main Authors: Wenchao Qu, Bao Hu, John W. Babich, Nicole Waterhouse, Marybeth Dooley, Shashikanth Ponnala, Julie Urgiles
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15556-7