Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization

Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization

Abstract Background The pathogenic roles of receptor-mediated sphingosine 1-phosphate (S1P) signaling in cerebral ischemia have been evidenced mainly through the efficacy of FTY720 that binds non-selectively to four of the five S1P receptors (S1P1,3,4,5). Recently, S1P1 and S1P2 were identified as s...

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Bibliographic Details
Main Authors: Bhakta Prasad Gaire, Mi-Ryoung Song, Ji Woong Choi
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Neuroinflammation
Subjects:
Transient focal cerebral ischemia
S1P3
CAY10444
Microglial activation
M1 polarization
ERK1/2
Online Access:http://link.springer.com/article/10.1186/s12974-018-1323-1

Internet

http://link.springer.com/article/10.1186/s12974-018-1323-1

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