Mutations of beta-amyloid precursor protein alter the consequence of Alzheimer’s disease pathogenesis

Mutations of beta-amyloid precursor protein alter the consequence of Alzheimer’s disease pathogenesis

Alzheimer’s disease is pathologically defined by accumulation of extracellular amyloid-β (Aβ). Approximately 25 mutations in β-amyloid precursor protein (APP) are pathogenic and cause autosomal dominant Alzheimer’s disease. To date, the mechanism underlying the effect of APP mutation on Aβ generatio...

Full description

Bibliographic Details
Main Authors: Nuo-Min Li, Ke-Fu Liu, Yun-Jie Qiu, Huan-Huan Zhang, Hiroshi Nakanishi, Hong Qing
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; Alzheimer′s disease; β-amyloid precursor protein; amyloid β; APP mutations; liquid chromatography-tandem mass chromatography; cellular localization; long Aβ; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=4;spage=658;epage=665;aulast=Li

Internet

http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=4;spage=658;epage=665;aulast=Li

Similar Items