Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors

Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors

Tyrosinase catalyzes two distinct sequential reactions in melanin biosynthesis: The hydroxylation of tyrosine to dihydroxyphenylalanine (DOPA) and the oxidation of DOPA to dopaquinone. Developing functional modulators of tyrosinase is important for therapeutic and cosmetic purposes. Given the abunda...

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Bibliographic Details
Main Authors: Joonhyeok Choi, Jun-Goo Jee
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:International Journal of Molecular Sciences
Subjects:
cheminformatics
docking simulation
drug repositioning
thiourea
tyrosinase
Online Access:http://www.mdpi.com/1422-0067/16/12/26114

Internet

http://www.mdpi.com/1422-0067/16/12/26114

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