Discovery of novel determinants of endothelial lineage using chimeric heterokaryons

Discovery of novel determinants of endothelial lineage using chimeric heterokaryons

We wish to identify determinants of endothelial lineage. Murine embryonic stem cells (mESC) were fused with human endothelial cells in stable, non-dividing, heterokaryons. Using RNA-seq, it is possible to discriminate between human and mouse transcripts in these chimeric heterokaryons. We observed a...

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Bibliographic Details
Main Authors: Wing Tak Wong, Gianfranco Matrone, XiaoYu Tian, Simion Alin Tomoiaga, Kin Fai Au, Shu Meng, Sayumi Yamazoe, Daniel Sieveking, Kaifu Chen, David M Burns, James K Chen, Helen M Blau, John P Cooke
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
Heterokaryons
Endothelial lineage
nuclear reprogramming
zebrafish
pou3f2
Online Access:https://elifesciences.org/articles/23588

Internet

https://elifesciences.org/articles/23588

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