Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea

Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea

Sensorineural hearing loss is most commonly caused by the death of hair cells in the organ of Corti, and once lost, mammalian hair cells do not regenerate. In contrast, other vertebrates such as birds can regenerate hair cells by stimulating division and differentiation of neighboring supporting cel...

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Bibliographic Details
Main Authors: Juan Cristobal Maass, Rende eGu, Martin L. Basch, Joerg eWaldhaus, Eduardo eMartin-Lopez, Anping eXia, John S. Oghalai, Stefan eHeller, Andrew K. Groves
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Cochlea
Regeneration
Notch
Hair cell
Supporting cell
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00110/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00110/full

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