Chronic HIV-1 Tat exposure alters anterior cingulate cortico-basal ganglia-thalamocortical synaptic circuitry, associated behavioral control, and immune regulation in male mice

Chronic HIV-1 Tat exposure alters anterior cingulate cortico-basal ganglia-thalamocortical synaptic circuitry, associated behavioral control, and immune regulation in male mice

HIV-1 selectively disrupts neuronal integrity within specific brain regions, reflecting differences in viral tropism and/or the regional differences in the vulnerability of distinct neuronal subpopulations within the CNS. Deficits in prefrontal cortex (PFC)-mediated executive function and the result...

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Bibliographic Details
Main Authors: Sara R. Nass, Yun K. Hahn, Virginia D. McLane, Neil B. Varshneya, M. Imad Damaj, Pamela E. Knapp, Kurt F. Hauser
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
C-C motif chemokine ligand 4
Interleukin-17A
Cortical layer V pyramidal neurons
HIV-associated neurocognitive disorders
Glutamic acid decarboxylase 67
Striatal medium spiny neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354620300429

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http://www.sciencedirect.com/science/article/pii/S2666354620300429

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