Systemic expression of Notch ligand Delta-like 4 during mycobacterial infection alters the T cell immune response
The Notch ligand Delta-like 4 (DLL4) is known to fine-tune the CD4+ T cell cytokine response. DLL4 is expressed on the surface of antigen presenting cells in a MyD88 dependent manner. We found that DLL4 expression was upregulated on bone marrow progenitor cells and antigen presenting cells in mice i...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-11-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00527/full |