IRF5 Is a Key Regulator of Macrophage Response to Lipopolysaccharide in Newborns

IRF5 Is a Key Regulator of Macrophage Response to Lipopolysaccharide in Newborns

Infections are a leading cause of mortality and morbidity in newborns. The high susceptibility of newborns to infection has been associated with a limited capacity to mount protective immune responses. Monocytes and macrophages are involved in the initiation, amplification, and termination of immune...

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Bibliographic Details
Main Authors: Anina Schneider, Manuela Weier, Jacobus Herderschee, Matthieu Perreau, Thierry Calandra, Thierry Roger, Eric Giannoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
M1/M2 macrophages
newborns
innate immunity
interferon regulatory factor 5
monocytes
GM-CSF
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01597/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01597/full

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